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KMID : 0384320030240010051
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Korean Journal of Family Medicine
2003 Volume.24 No. 1 p.51 ~ p.57
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Serum Insulin-Like Growth Factor I and Its Relating Factors in Healthy Korean Adults Aged over 40 Years
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Lee Duk-Chul
Lee Hye-Ree
Choi Young-Eun
Moon Sun-Im
Oh Eun-Sook
Oh Ki-Won
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Abstract
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Background: There is a clinical need for a reference value based on healthy adults in Korea. The aim of this study was to define IGF-1 concentration in healthy Korean adults and to investigate the factors relative to IGF-1 level.
Methods: By reviewing the medical records of a hospital in Korea, healthy 112 men and 109 women aged over 40 years were studied. We determined the serum IGF-1 levels of both groups according to age, sex, health behaviors, lipid profile, bone mineral density, serum albumin, waist circumference, body mass index, total testosterone, and FSH.
Results: IGF-1 had no sexual difference in any age group (258.7±84.3 ng/㎖ for men, 263.7±86.8 ng/㎖ for women), but correlated negatively with age (r=-0.43 and -0.35 for men and women, respectively). The mean decline was 49.6 ng/㎖ and 43.9 ng/㎖ per 10 years for men and women, respectively. IGF-1 correlated positively with serum albumin, total cholesterol, and bone mineral density of spine and femur neck. The multiple regression analysis showed that the most powerful factors influencing IGF-1 level was serum albumin (R2; 0.13) followed by age, bone mineral density of femur neck, and total cholesterol.
Conclusion: We present a reference value for IGF-1 in healthy Korean adults aged over 40 years. The most powerful factor influencing IGF-1 level was serum albumin.
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KEYWORD
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insulin-like growth factor I, adult growth hormone deficiency, growth hormone, aging
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